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Scientific Backing: Recommendations are based on clinical studies and up-to-date nutritional guidelines

Acknowledgements We gratefully acknowledge the resources provided by the Institute for Precision Health and participating patients from the UCLA ATLAS Community Health Initiative ( The UCLA ATLAS Community Health Initiative in collaboration with UCLA ATLAS Precision Health Biobank is a program of the Institute for Precision Health, which directs and supports the biobanking and genotyping of biospecimen samples from participating patients from UCLA in collaboration with the David Geffen School of Medicine, UCLA Clinical and Translational Science Institute and UCLA Health

CJC-1295 Without DAC and DPP-4 Resistance Research Research that led to the identification of the tetrasubstituted GRF backbone confirmed that all maleimido derivatives of hGRF(1-29) sharing the same four amino acid substitutions showed enhanced in vitro stability against DPP-IV and retained bioactivity in GH secretion assays in cultured rat anterior pituitary cells establishing that the tetrasubstituted scaffold itself is responsible for DPP-4 resistance, independent of the DAC albumin-binding moiety

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Tirzepatide also works on a second receptor called GIP (glucose-dependent insulinotropic polypeptide)